Table 4. Free energy values and additivity relationships between substituents for ceftazidime hydrolysis.
ΔΔG | ΔGi | |
---|---|---|
KPC2 | 0 | - |
P104R | -0.63 | - |
V240G | -0.42 | - |
H274Y | -0.57 | - |
P104R:V240G | -1.02 | 0.03 |
P104R:H274Y | -1.13 | 0.07 |
V240G:H274Y | -0.95 | 0.04 |
Calculated from k cat/Km of ceftazidime hydrolysis.