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. 2015 May 29;32(7):187. doi: 10.1007/s12032-015-0633-8

Fig. 2.

Fig. 2

Effects of c-Myc–LDHA axis on aerobic glycolysis in pancreatic cancer cells in vitro. a The protein level of c-Myc and LDHA was detected by western blotting in AsPC-1 and SW1990 cells after c-Myc-specific siRNA treatment. Glucose utilization (b) and lactate production (c) were measured after c-Myc was silenced (si-Ctrl vs. si–c-Myc-1 or si–c-Myc-2; *P < 0.05; **P < 0.01). d The interference efficiency of LDHA was detected by western blotting in AsPC-1 and SW1990 cells. Glucose utilization (e) and lactate production (f) were measured after LDHA was silenced (si-Ctrl vs. si-LDHA-1 or si-LDHA-2; *P < 0.05; **P < 0.01)