Table 2.
Regression analysis for particle size, zeta potential, drug loading efficiency, and RE300%.
| Responses | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Factor | Particle size | Zeta potential | Drug loading efficiency % | RE300% | ||||||||
| C.E | Std. error | P value | C.E | Std. error | P value | C.E | Std. error | P value | C.E | Std. error | P value | |
| Int | +561.70 | 24.58 | 0.1004 | −29.37 | 0.64 | 0.0118 | +33.70 | 1.03 | <0.0001 | +81.31 | 3.06 | 0.0289 |
| X 1 | — | — | — | +1.27 | 0.73 | 0.0969 | — | — | — | +0.84 | 1.48 | 0.5760 |
| X 2 | −60.02 | 30.53 | 0.0626 | — | — | — | — | — | — | +0.73 | 1.59 | 0.6516 |
| X 3 | −3.45 | 27.94 | 0.9030 | — | — | — | +6.31 | 1.18 | <0.0001 | −0.28 | 1.43 | 0.8456 |
| X 4 | — | — | — | +0.34 | 0.72 | 0.6386 | −3.21 | 1.15 | 0.0106 | — | — | — |
| X 1 2 | — | — | — | — | — | — | — | — | — | 5.29 | 3.70 | 0.1708 |
| X 2 2 | — | — | — | — | — | — | — | — | — | 5.88 | 2.88 | 0.0565 |
| X 3 2 | — | — | — | — | — | — | — | — | — | −11.87 | 3.70 | 0.0052 |
| X 1 X 3 | — | — | — | — | — | — | — | — | — | 3.87 | 1.52 | 0.0211 |
| X 1 X 4 | — | — | — | −2.41 | 0.78 | 0.0053 | — | — | — | — | — | — |
| X 2 X 3 | +66.11 | 32.73 | 0.0563 | — | — | — | — | — | — | — | — | — |
|
| ||||||||||||
| Lack of fit values | ||||||||||||
| F value | 0.52 | 1.05 | 2.78 | 1.18 | ||||||||
| P value | 0.8524 | 0.5270 | 0.1315 | 0.4595 | ||||||||
X 1: CaCl2 percent, X 2: homogenization speed, X 3: agar percent, X 4: HPβCD percent, C.E: coefficient estimate in terms of actual factors, and Int: intercept; the positive sign of the factor represents a synergistic effect on the response, while a negative sign means an antagonist relationship.