Skip to main content
. 2015 Jun 1;10(6):e0128474. doi: 10.1371/journal.pone.0128474

Table 3. Multivariate regression analysis using area under the curve of pain-related BA3, BA6 and BA24 activation in the left hemisphere as predictors of pain and distress ratings in Waking condition (step-1) and after entering SHCS scores as a covariate (step-2).

Pain Rating Distress Rating      
BA Region Estimate SE t  P Estimate SE t  P
Control 1 Control 7
Intercept 4.971 0.509 9.76 <.0001 5.371 0.466 11.53 <.0001
BA3-LH 0.207 0.068 3.04 0.008 0.106 0.071 1.49 0.1542
BA24-LH 0.052 0.35 0.15 0.884 0.459 0.199 2.3 0.034
BA24-RH 0.52 0.5 1.04 0.314 - - - -
BA6-LH 0.008 0.108 0.07 0.943 - - - -
Control 2 Control 8
Intercept 4.53 0.638 7.11 <.0001 5.079 0.725 7 <.0001
SHCS 0.19 0.169 1.12 0.281 0.095 0.177 0.54 0.599
BA3-LH 0.237 0.072 3.26 0.006 0.121 0.078 1.55 0.14
BA24-LH 0.251 0.39 0.64 0.531 0.447 0.205 2.18 0.044
BA24-RH 0.24 0.555 0.43 0.673 - - - -
BA6-LH -0.034 0.113 -0.3 0.767 - - - -
Hypoalgesia 3 Hypoalgesia 9
Intercept 5.26 0.289 18.21 <.0001 - - - -
BA3-LH 0.196 0.041 4.77 0.0002 - - - -
Hypoalgesia 4 Hypoalgesia 10
Intercept 5.67 0.548 10.34 <.0001 - - - -
SHCS -0.15 0.171 -0.88 0.391 - - - -
BA3-LH 0.19 0.042 4.47 0.0003 - - - -
Hyperalgesia 5 Hyperalgesia 11
Intercept 5.055 0.454 11.13 <.0001 5.57 0.364 15.29 <.0001
BA3-LH 0.26 0.065 3.98 0.001 0.213 0.052 4.1 0.0007
BA6-LH 0.158 0.116 1.36 0.191 - - - -
Hyperalgesia 6 Hyperalgesia 12
Intercept 4.213 0.514 8.19 <.0001 4.683 0.463 10.11 <.0001
SHCS 0.352 0.138 2.55 0.021 0.34 0.13 2.62 0.0179
BA3-LH 0.277 0.057 4.85 0.0002 0.219 0.045 4.85 0.0001
BA6-LH 0.121 0.102 1.19 0.251 - - - -

1 Step-1: F(4,19) = 8.79, p = 0.0007; R-Square = 0.70, Adj. R-Square = 0.62

2 Step-2:Entering SHCS: F(5,19) = 7.41, p = 0.0014; R-Square = 0.72, Adj. R-Square = 0.63

3 Step-1:F(1,19) = 22.71, p = 0.0002; R-Square = 0.56, Adj. R-Square = 0.53

4 Step-2: Entering SHCS: F(2,19) = 11.60, p = 0.0007; R-Square = 0.58, Adj. R-Square = 0.53

5 Step-1: F(2,19) = 16.75, p<.0001; R-Square = 0.66, Adj. R-Square = 0.62

6 Step-2: Entering SHCS: F(3,19) = 16.94, p<.0001; R-Square = 0.76, Adj. R-Square = 0.71

7 Step-1: F(4,19) = 7.95, p = 0.0036; R-Square = 0.48, Adj. R-Square = 0.42

8 Step-2: Entering SHCS: F(3,19) = 5.18, p = 0.011; R-Square = 0.49, Adj. R-Square = 0.39

9 Non Significant

10 Non Significant

11 Step-1: F(1,19) = 16.81, p =. 0007; R-Square = 0.48, Adj. R-Square = 0.45

12 Step-2: Entering SHCS: F(2,19) = 14.58, p =. 0002; R-Square = 0.63 Adj. R-Square = 0.59