Table 5. Multivariate regression analysis of changes in pain-related BA3 activation of hypoalgesia and hyperalgesia vs control condition in the left and right hemisphere (LH and RH) in relation to the changes in pain ratings of treatments vs control (Step-1), and after entering SHCS scores as a covariate (step-2).

Waking					Hypnosis
BA Region	Estimate	SE	t	P	Estimate	SE	t	P
Control vs Hypoalgesia 1					Control vs Hypoalgesia 7
Intercept	0.976	0.164	5.97	<0.0001	0.36	0.312	1.15	0.264
BA3-LH	0.047	0.017	2.76	0.013	0.407	0.505	0.81	0.427
BA3-RH	0.046	0.056	0.82	0.425	-0.123	0.14	-0.88	0.392
Control vs Hypoalgesia 2					Control vs Hypoalgesia 8
Intercept	0.301	0.302	1	0.334	0.029	0.518	0.06	0.957
SHCS	0.267	0.106	2.53	0.022	0.15	0.187	0.81	0.432
BA3-LH	0.049	0.049	0.99	0.338	0.347	0.17	2.04	0.06
BA3-RH	0.052	0.049	1.07	0.3	-0.079	0.151	-0.52	0.608
Hyperalgesia vs Control 3					Hyperalgesia vs Control 9
Intercept	-0.067	0.123	-0.55	0.589	0.421	0.3	1.4	0.178
BA3-LH	0.126	0.04	3.11	0.006	0.006	0.273	0.02	0.981
BA3-RH	0.036	0.036	0.99	0.335	0.328	0.279	1.17	0.257
Hyperalgesia vs Control 4					Hyperalgesia vs Control 10
Intercept	-0.786	0.211	-3.73	0.002	-0.876	0.406	-2.15	0.047
SHCS	0.291	0.077	3.79	0.002	0.557	0.146	3.82	0.001
BA3-LH	0.111	0.03	3.63	0.002	0.046	0.204	0.23	0.823
BA3-RH	-0.001	0.029	-0.02	0.986	0.234	0.21	1.12	0.281
Hyperalgesia vs Hypoalgesia 5					Hyperalgesia vs Hypoalgesia 11
Intercept	0.816	0.219	3.73	0.002	0	0.572	0	0.999
BA3-LH	0.128	0.06	2.13	0.049	0.737	0.196	3.75	0.002
BA3-RH	0.097	0.05	1.93	0.07	-0.271	0.192	-1.41	0.176
Hyperalgesia vs Hypoalgesia 6					Hyperalgesia vs Hypoalgesia 12
Intercept	-0.37	0.337	-1.1	0.288	-1.008	0.675	-1.49	0.155
SHCS	0.493	0.123	4	0.001	0.564	0.246	2.29	0.036
BA3-LH	0.095	0.037	2.59	0.019	0.548	0.194	2.82	0.012
BA3-RH	0.073	0.046	1.57	0.137	-0.167	0.178	-0.94	0.361

¹ Step-1: F(2,19) = 2.22, p = 0.139; R-Square = 0.21, Adj. R-Square = 0.11

² Step-2 entering SHCS: F(3,19) = 4.08, p = 0.024; R-Square = 0.43, Adj. R-Square = 0.33

³ Step-1: F(2,19) = 9.40, p = 0.0018; R-Square = 0.52, Adj. R-Square = 0.47

⁴ Step-2 entering SHCS: F(3,19) = 16.00, p<.0001; R-Square = 0.75, Adj. R-Square = 0.70

⁵ Step-1: F(2,19) = 7.90, p = 0.0037; R-Square = 0.48, Adj. R-Square = 0.42

⁶ Step-2 entering SHCS: F(3,19) = 15.26, p<.0001; R-Square = 0.74, Adj. R-Square = 0.69

⁷ Step-1: F(2,19) = 9.67 p = 0.0016; R-Square = 0.53, Adj. R-Square = 0.48

⁸ Step-2 entering SHSC: F(3,19) = 6.53, p = 0.043; R-Square = 0.55, Adj. R-Square = 0.46

⁹ Step-1: F(2,19) = 6.89, p = 0.0065; R-Square = 0.45, Adj. R-Square = 0.38

¹⁰ Step-2 entering SHSC: F(3,19) = 13.13, p =. 0001; R-Square = 0.71, Adj. R-Square = 0.66

¹¹ Step-1: F(2,19) = 15.34, p = 0.0002; R-Square = 0.64, Adj. R-Square = 0.60

¹² Step-2 entering SHSC: F(3,19) = 14.52, p<.0001; R-Square = 0.73, Adj. R-Square = 0.68