Table 2. Hazard ratios (HRs) for developing breast cancer in relation to metabolic syndrome and number of metabolic syndrome components.
| Cases/Controls | HR 1 | HR 2 | |
|---|---|---|---|
| Whole cohort | |||
| Absence of metabolic syndrome (<3 components) | 387/406 | 1 | 1 |
| Presence of metabolic syndrome (≥3 components) | 206/149 | 1.50 (1.14–1.97) | 1.52 (1.14–2.02) |
| P interaction 3 | 0.001 | 0.001 | |
| Number of components (3 categories) | |||
| 0 | 86/115 | 1 | 1 |
| 1–2 | 301/291 | 1.32 (0.94–1.85) | 1.33 (0.94–1.89) |
| ≥3 | 206/149 | 1.85 (1.28–2.69) | 1.91 (1.28–2.84) |
| P trend | 0.001 | 0.001 | |
| Postmenopausal women | |||
| Absence of metabolic syndrome (<3 components) | 153/164 | 1 | 1 |
| Presence of metabolic syndrome (≥3 components) | 133/86 | 1.85 (1.28–2.69) | 1.80 (1.22–2.65) |
| Number of components (3 categories) | |||
| 0 | 17/30 | 1 | 1 |
| 1–2 | 136/134 | 1.64 (0.82–3.27) | 1.89 (0.89–4.01) |
| ≥3 | 133/86 | 2.80 (1.38–5.71) | 3.12 (1.43–6.79) |
| P trend | 0.001 | 0.001 | |
| Premenopausal women | |||
| Absence of metabolic syndrome (<3 components) | 201/201 | 1 | 1 |
| Presence of metabolic syndrome (≥3 components) | 57/56 | 0.72 (0.45–1.15) | 0.71 (0.43–1.16) |
| Number of components (3 categories) | |||
| 0 | 62/71 | 1 | 1 |
| 1–2 | 139/130 | 1.11 (0.73–1.68) | 1.12 (0.72–1.74) |
| ≥3 | 57/56 | 0.77 (0.45–1.34) | 0.77 (0.43–1.40) |
| P trend | 0.445 | 0.478 | |
1Stratified by age (5-year classes) and centre.
2Adjusted for menopausal status (whole cohort model only), number of full-term pregnancies, age at menarche, smoking status, education, physical activity, and alcohol intake; stratified by age (5-year classes) and centre.
3P for interaction between metabolic syndrome and menopausal status.