Table 3. Hazard ratios (HRs) for developing breast cancer in relation to metabolic syndrome components.

	Cases/Controls	HR 1	HR 2
Whole cohort
High waist circumference
No	254/249	1	1
Yes	339/306	1.11 (0.86–1.42)	1.07 (0.82–1.39)
P interaction 3		0.101	0.130
High triglycerides
No	439/430	1	1
Yes	154/125	1.24 (0.93–1.66)	1.22 (0.90–1.64)
P interaction 3		0.355	0.530
Low HDL cholesterol
No	494/464	1	1
Yes	99/91	1.27 (0.90–1.80)	1.25 (0.88–1.79)
P interaction 3		0.503	0.612
High blood pressure
No	249/256	1	1
Yes	344/299	1.22 (0.94–1.58)	1.24 (0.95–1.63)
P interaction 3		0.031	0.023
High fasting glucose
No	382/414	1	1
Yes	211/141	1.42 (1.10–1.84)	1.47 (1.13–1.91)
P interaction 3		0.001	0.004
Postmenopausal women
High waist circumference
No	96/88	1	1
Yes	190/162	1.12 (0.75–1.63)	1.04 (0.69–1.57)
High triglycerides
No	195/177	1	1
Yes	91/73	1.25 (0.84–1.86)	1.21 (0.80–1.83)
Low HDL cholesterol
No	240/212	1	1
Yes	46/38	1.24 (0.75–2.07)	1.11 (0.64–1.93)
High blood pressure
No	71/75	1	1
Yes	215/175	1.46 (0.96–2.22)	1.51 (0.96–2.39)
High fasting glucose
No	161/182	1	1
Yes	125/68	1.95 (1.34–2.85)	1.89 (1.29–2.77)
Premenopausal women
High waist circumference
No	135/132	1	1
Yes	123/125	0.80 (0.54–1.17)	0.77 (0.51–1.16)
High triglycerides
No	210/214	1	1
Yes	48/43	1.04 (0.65–1.66)	1.07 (0.66–1.75)
Low HDL cholesterol
No	219/212	1	1
Yes	39/45	1.06 (0.64–1.76)	0.99 (0.58–1.67)
High blood pressure
No	154/152	1	1
Yes	104/105	0.83 (0.57–1.21)	0.88 (0.60–1.31)
High fasting glucose
No	189/193	1	1
Yes	69/64	0.75 (0.50–1.12)	0.80 (0.52–1.22)

¹Stratified by age (5-year classes) and centre.

²Adjusted for menopausal status (whole cohort model only), number of full-term pregnancies, age at menarche, smoking status, education, physical activity, and alcohol intake; stratified by age (5-year classes) and centre.

³P for interaction between metabolic syndrome components and menopausal status.