Fig 5. Protection of mice from lethal H7N7 influenza virus challenge.

Mice (n = 10/groups) were immunized subcutaneously on day 0 and 28. All groups were challenged intranasally with 5 MLD₅₀ of mouse-adapted H7N7 virus on day 49. Mice were monitored for survival for 14 days and the results were expressed in percent survival (5A). Weight loss of the mice groups was also monitored throughout the 14 day observation period and the results were expressed in percent body weight compared to the beginning of the trial (5B). Each point represents the arithmetic mean (n = 6) value ± SD (***P<0.0001, when compared to Bac-HA vaccinated mice group); # represents ≥33.3 survival in the group.