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. 2015 May 19;2015:690878. doi: 10.1155/2015/690878

Table 2.

Mutations and their allele frequencies observed in the OGG1 gene in breast cancer patients.

Mutation/exon
Chr3 (GRCh37)
Patients Controls aOdds ratio (95% CI) b p value
Number Allele frequency
Minor/major
Number Allele frequency
Minor/major
g.9792260 insert_T Intron 1 34 T 0.09/0.91 07 T 0.35/0.65 3.80 (1.67 to 8.66) 0.001
g.9793680G>A Intron 3 (rs55846930) 19 A 0.05/G 0.95 00 A 00/G 1.0 14.65 (1.95 to 109.90) 0.009
g.9793748G>A Intron 3 14 A 0.04/G 0.96 00 A 00/G 1.0 10.70 (1.40 to 81.64) 0.02
g.9798336T>G Intron 5 10 G 0.03/T 0.97 06 G 0.40/T 0.60 1.25 (0.45 to 3.46) 0.67
g.9798349T>A Intron 5 34 A 0.09/T 0.91 02 A 0.10/T0.90 13.30 (3.18 to 55.70) 0.0004
g.9792109delT splice site Intron 1 26 0.07/T 0.93 00 00/T 1.0 20.07 (2.71 to 148.53) 0.003
g.9798307T>G splice site Intron 5 16 G 0.04/T 0.96 00 G 00/T 1.0 12.11 (1.60 to 91.70) 0.01
g.9798502T>G splice site Intron 6 18 G 0.05/T 0.95 00 G 00/T 1.0 13.68 (1.82 to 102.90) 0.01
g.9800972T>G splice site intron 7a 36 G 0.10/T 0.90 00 G 00/T 1.0 28.85 (3.87 to 207.70) 0.001
g.9798848G>A 3′UTR 37 A 0.10/G 0.90 00 A 00/G 1.0 29.20 (3.98 to 213.74) 0.001
g.9798896T>C 3′UTR 48 C 0.13/T 0.87 03 C 0.15/T 0.85 12.85 (3.97 to 41.56) <0.0001
g.9793544T>G Exon 3, Val159Gly 18 G 0.05/T 0.95 00 G 00/T 1.0 13.68 (1.82 to 102.90) 0.01
g.9796483G>A Exon 4, Gly221Arg (TMP_ESP_3_9796483) 22 A 0.06/G 0.94 00 A 00/G 1.0 16.85 (2.26 to 125.53) 0.005
g.9798773C>G Exon 6d Ser326Cys (rs1052133) (CM993185) 24 G 0.06/C 0.94 00 G 00/C 1.0 18.45 (2.49 to 136.99) 0.004
g.9807669G>A Exon 8, Trp375STOP 17 A 0.05/G 0.95 00 A 00/G 1.0 12.90 (1.71 to 97.28) 0.01

OR: odds ratio; CI: confidence interval. aORs for logistic regression analysis. b p < 0.05, by χ 2-test for trend.