. Author manuscript; available in PMC: 2015 Aug 1.

Published in final edited form as: Transl Res. 2014 Mar 4;164(2):110–121. doi: 10.1016/j.trsl.2014.02.004

Table III.

Hazard risk association of non-HLA genes with islet autoimmunity and T1D in a DAISY non-Hispanic white population using multivariate analyses, adjusted for HLA-DR3/4,DQB1*0302 and family history of T1D as reported by Steck et al¹⁷

Gene	SNP	Risk allele	Islet autoimmunity		T1D
Gene	SNP	Risk allele	Hazard risk (95% CI)	P value	Hazard risk (95% CI)	P value
INS	rs689	A	1.32 (0.94–1.85)	0.11	1.75 (1.08–2.83)	0.02
PTPN2	rs1893217	G	1.42 (1.02–1.99)	0.04	0.99 (0.60–1.66)	0.98
PTPN22	rs2476601	T	1.87 (1.31–2.68)	0.001	1.74 (1.04–2.90)	0.03
UBASH3A	rs11203203	A	1.46 (1.11–1.91)	0.01	1.83 (1.28–2.64)	0.001

Abbreviations: CI, confidence interval; DAISY, Diabetes and Autoimmunity Study in the Young; HLA, human leukocyte antigen; SNP, single nucleotide polymorphism; T1D, type 1 diabetes.