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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Clin Cancer Res. 2015 Mar 4;21(11):2580–2590. doi: 10.1158/1078-0432.CCR-14-2191

Figure 5. YAP mediates chemoresistance in EC cells.

Figure 5

A&B. SKGT-4 (PIN20YAP) EAC cells and KATO-TN (PIN20YAP) ESCC cells with (DOX+) or without (DOX-) YAP induction and treated with 5-FU(A) or Docetaxcel (B) at the dosage indicated for six days then cell growth was determined using MTS as indicated in Materials and Methods. C. JHESO cells and its YAP knockdown cells (YAPsh2, YAPsh3) were treated with 5-FU at the dosage indicated for five days; cell growth was determined using MTS. D. Cell growth was determined using MTS in Flo-1 and its 5-FU resistant clone (Flo-1 RF) under the treatment of 5-FU at different dosage(left panel). Immunoblotting for YAP1, EGFR, ALDH1 and MCL-1 was performed in Flo-1 and its 5-FU resistant clone (Flo-1 RF) as indicated in Materials and Methods (right panel).