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. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: J Thromb Haemost. 2015 May 10;13(6):1090–1102. doi: 10.1111/jth.12956

Fig. 4. Antagonism of C5a with C5aRA does not equalize outcomes for Cpb2−/− and WT mice in polymicrobial sepsis.

Fig. 4

(A) Kaplan-Meier survival curves comparing untreated Cpb2−/−, C5aRA-treated Cpb2−/−, untreated WT to C5aRA-treated WT mice in the CLP model (n=10 each genotype; C5aRA treated vs untreated: p=0.0422). (B-H) Groups of Cpb2−/− and WT mice with CLP untreated or treated with C5aRA were sacrificed after 48 hours. Data are shown from one of two independent experiments with similar results. (B) Protein in peritoneal lavage. (C) Cells in peritoneal lavage. (D) Lung edema (E) ALT, (F) AST, (G) BUN, and (H) Creatinine in plasma at 48 hours. B–H: WT n=5, Cpb2−/− n=6, WT + C5aRA n= 6, Cpb2−/− + C5aRA n=8. Closed columns: untreated; open columns treated. Data were analyzed by two-way ANOVA with post-hoc Fisher's least significant difference correction. * p<0.05; ** p<0.01; *** p<0.001.