Table 2.
Effect of biguanides on plasma analytes
| Analyte | Control | Metformina | Phenformin | Buformin | Overall P value |
|---|---|---|---|---|---|
| Glucose (mg/dL) | 125.4 ± 12.9 | 128.5 ± 11.7 | 128.7 ± 17.4 | 130.7 ± 23.9 | 0.697 |
| Insulin (ng/mL) | 1.2 ± 0.3 | 1.1 ± 0.2 | 1.1 ± 0.3 | 1.1 ± 0.4 | 0.879 |
| IGF-l (ng/mL) | 328.7 ± 94.8b | 332.5 ± 74.4b | 254.2 ± 62.4c | 229.4 ± 61.5c | < 0.001 |
| IGFBP3 (ng/mL) | 112.9 ± 29.9 | 113.0 ± 18.8 | 107.2 ± 24.3 | 106.3 ± 18.5 | 0.542 |
| Glucagon (pg/mL) | 73.5 ± 59.9b | 63.9 ± 40.7b,d | 26.8 ± 12.1c | 31.1 ± 9.5c,d | 0.002 |
| Leptin (ng/mL) | 1.9 ± 0.7 | 1.8 ± 0.7 | 1.5 ± 0.4 | 1.5 ± 0.6 | 0.087 |
| Adiponectin (ng/mL) | 18.8 ± 3.7b | 18.6 ± 4.0b | 20.8 ± 3.3b,c | 22.4 ± 6.2c | 0.003 |
| Total Cholesterol (mg/dL) | 101.7 ± 8.1 | 104.5 ± 14.9 | 100.2 ± 16.5 | 100.3 ± 13.0 | 0.564 |
| HDL Cholesterol (mg/dL) | 50.6 ± 9.1b | 55.2 ± 10.0b,c | 55.5 ± 11.1b,c | 60.4 ± 12.0c | 0.0068 |
| LDL Cholesterol (mg/dL) | 31.6 ± 11.4b,d | 30.6 ± 8.2b,d | 25.9 ± 9.3b,c,d | 21.1 ± 9.1c | 0.0001 |
| Triglyceride (mg/dL) | 97.6 ± 17.1 | 93.7 ± 20.6 | 94.0 ± 18.1 | 94.2 ± 11.9 | 0.7973 |
Values are means ± SD, n = 30/group. Data were evaluated by ANOVA with post hoc comparison by the method of Tukey. Values within a row with different superscripts were statistically different by post hoc multiple comparisons, P < 0.05.
a
Biguanide was provided in the diet at concentrations of: 9.3mmol metformin/kg diet, 7.6 mmol buformin/kg diet, or 5.0 mmol phenformin/kg diet.