Table 1.

Association of genotypes with MPM (N = 1,206) compared with SPM (N = 2,469) in the GEM Study

Chromosome	Gene neighborhood	SNP	a/A	Additive Model
				Per allele OR (95% CI)a	P value
1	ARNT	rs7412746	C/T	0.97 (0.87–1.08)	0.56
1	PARP1	rs3219090	A/G	0.90 (0.80–1.01)	0.07
1	PARP1	rs2695238	C/G	0.96 (0.85–1.07)	0.43
1	NID1	rs3768080	G/A	0.94 (0.85–1.05)	0.25
1	NID1	rs10754833	C/T	0.93 (0.84–1.04)	0.20
2	CASP8	rs6735656b	G/T	1.08 (0.96–1.22)	0.21
2	CASP8	rs13016963	A/G	1.10 (0.99–1.22)	0.09
5	TERT	rs2242652	T/C	1.04 (0.91–1.18)	0.60
5	TERT	rs2853676	A/G	1.07 (0.95–1.19)	0.28
5	TERT	rs13356727	G/A	1.10 (0.98–1.22)	0.10
5	TERT;CLPTM1L	rs4975616	G/A	1.06 (0.94–1.18)	0.34
5	TERT;CLPTM1L	rs401681	T/C	1.14 (1.02–1.26)	0.02
5	SLC45A2	rs16891982	C/G	0.71 (0.45–1.12)	0.14
5	SLC45A2	rs35391	T/C	0.70 (0.39–1.28)	0.25
5	SLC45A2	rs26722	T/C	0.66 (0.36–1.23)	0.19
5	SLC45A2	rs13289	G/C	0.99 (0.88–1.10)	0.81
6	IRF4	rs12203592	T/C	1.10 (0.97–1.24)	0.14
6	IRF4	rs872071	A/G	0.96 (0.86–1.07)	0.43
9	TYRP1	rs1408799	T/C	0.90 (0.80–1.01)	0.07
9	TYRP1	rs2733832	C/T	0.87 (0.78–0.97)	0.01
9	MTAP	rs2218220	T/C	0.88 (0.79–0.98)	0.02
9	MTAP	rs1335510d	G/T	0.82 (0.73–0.91)	0.0003
9	MTAP	rs7023329	G/A	0.87 (0.78–0.96)	0.008
9	MTAP	rs10811629	G/A	0.85 (0.76–0.94)	0.002
11	CCND1	rs11604821	G/A	1.03 (0.92–1.15)	0.64
11	CCND1	rs1485993	T/C	1.03 (0.92–1.15)	0.57
11	CCND1	rs11263498	T/C	1.01 (0.91–1.13)	0.82
11	TYR	rs1042602	A/C	0.91 (0.82–1.02)	0.11
11	TYR	rs10765198	C/T	1.22 (1.10–1.36)	0.0003
11	TYR	rs1847142	A/G	1.21 (1.09–1.35)	0.0004
11	TYR	rs10830253d	G/T	1.23 (1.10–1.37)	0.0002
11	ATM	rs12278954c	A/C	0.91 (0.78–1.05)	0.20
15	OCA2	rs1800407	A/G	1.10 (0.92–1.32)	0.29
15	OCA2	rs1800401	T/C	1.11 (0.86–1.42)	0.43
15	HERC2	rs1129038	G/A	0.99 (0.87–1.13)	0.88
15	HERC2	rs12913832	A/G	1.00 (0.88–1.13)	0.97
20	ASIP	rs17305657	C/T	1.12 (0.95–1.33)	0.18
20	ASIP	rs4911414	T/G	1.10 (0.99–1.23)	0.08
20	PIGU	rs910873	A/G	1.16 (0.99–1.36)	0.07
20	PIGU	rs17305573	C/T	1.15 (0.96–1.36)	0.12
20	NCOA6	rs4911442	G/A	1.19 (1.03–1.38)	0.02
20	MYH7B	rs1885120	C/G	1.15 (0.97–1.36)	0.11
20	LOC647979	rs1204552	A/T	1.10 (0.91–1.32)	0.32
21	MX2	rs45430	G/A	0.87 (0.77–0.97)	0.01
22	PLA2G6	rs6001027	G/A	1.03 (0.92–1.16)	0.61
22	PLA2G6	rs132985	T/C	0.96 (0.87–1.07)	0.51
22	PLA2G6	rs738322	G/A	0.95 (0.85–1.06)	0.35

NOTE: Limited to Caucasians. Bold type indicates P values < 0.05.

Abbreviations: a, minor allele; A, major allele.

^aAdjusted for age at diagnosis, sex, age by sex, and study center.

^brs6735656 is a proxy for rs10931936 (r²=0.965).

^crs12278954 is a proxy for rs1801516 (r²=1.00).

^dThe MTAP and TYR loci each had more than one SNP with a significant association (P value<.05). SNPs with the strongest association in stepwise logistic regression models are noted.