Table 2.
Association of a PARP1 haplotype with multiple primary melanoma in the GEM study
Gene Haplotype | SNP | Haplotype frequency | OR (95% CI)a, b | Global P value | |
---|---|---|---|---|---|
1 | 2 | ||||
PARP1: rs3219090 (SNP1), rs2695238 (SNP2) | |||||
1 | G | G | 0.672 | 1.00 (reference) | 0.03 |
2 | A | C | 0.300 | 0.93 (0.83–1.05) | |
3 | A | G | 0.017 | 0.53 (0.34–0.81) | |
4 | G | C | 0.011 | 0.93 (0.56–1.56) |
The reference category is the haplotype with the highest frequency.
Adjusted for age, sex, age by sex, and study center.