. Author manuscript; available in PMC: 2016 Jun 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2015 Apr 2;24(6):992–997. doi: 10.1158/1055-9965.EPI-14-1426

Table 3.

Genotype and haplotype associations with MPM (N = 1,074) compared with SPM (N = 2,137) for participants with no missing data in the GEM Study

Gene neighborhood	SNP(s)	Model	OR (95% CI)^a	P value	OR (95% CI)^b	P value	OR (95% CI)^c	P value
Genotypes
TERT;CLPTM1L	rs401681	ADD	1.21 (1.08–1.35)	0.001	1.20 (1.07–1.35)	0.0006	1.19 (1.06–1.33)	0.004
TYRP1	rs2733832	ADD	0.83 (0.74–0.94)	0.0020	0.85 (0.75–0.95)	0.0009	0.85 (0.76–0.96)	0.006
MTAP	rs1335510	ADD	0.80 (0.71–0.89)	0.00010	0.80 (0.71–0.90)	0.0004	0.81 (0.72–0.91)	0.0005
TYR	rs10830253	ADD	1.23 (1.09–1.38)	0.0005	1.19 (1.06–1.33)	0.003	1.20 (1.06–1.34)	0.003
NCOA6	rs4911442	ADD	1.18 (1.01–1.38)	0.03	1.16 (0.99–1.35)	0.07	1.16 (0.99–1.35)	0.06
MX2	rs45430	ADD	0.87 (0.77–0.97)	0.02	0.87 (0.77–0.98)	0.02	0.85 (0.75–0.96)	0.008
Haplotype
PARP1	rs3219090; rs2695238	AC^d	0.97 (0.85–1.09)	0.14	0.99 (0.87–1.12)	0.22	0.99 (0.88–1.13)	0.22
PARP1	rs3219090; rs2695238	AG^d	0.52 (0.29–0.92)		0.55 (0.31–0.97)		0.55 (0.31–0.97)
PARP1	rs3219090; rs2695238	GC^d	1.13 (0.64–1.97)		1.09 (0.62–1.91)		1.10 (0.62–1.95)

NOTE: Participants were included who had no missing data for phenotypic index, back nevus counts, or genotypes or haplotyes included in the table.

Abbreviations: ADD; additive.

Adjusted for age at diagnosis, sex, age by sex, study center.

Adjusted for age at diagnosis, sex, age by sex, study center, phenotypic index, and back nevi (0–10, >10).

Adjusted for age at diagnosis, sex, age by sex, study center, phenotypic index, back nevi (0–10, >10), and all genotypes/haplotypes in the table.

Reference category determined by the haplotype with the highest frequency.