Table 2.

Most Prevalent Non-Hematologic Toxicities. Number of patients with at least one instance of listed toxicities through the 1^st cycle and through all cycle. The worst grade toxicity is reported.

Toxicity	Dose Level 1 (4.5mg/m2 - Six Patients)		Dose Level 2 (9mg/m2 - Three Patients)		Dose Level 3 (18mg/m2 - Three Patients)		Dose Level 4 (36mg/m2 - Six Patients)
	1st cycle (All cycles)		1st cycle (All cycles)		1st cycle (All cycles)		1st cycle (All cycles)
	G1 & G2	G3 & G4	G1 & G2	G3 & G4	G1 & G2	G3 & G4	G1 & G2	G3 & G4
General
Fatigue	2 (5)	0 (0)	0 (1)	0 (0)	3 (3)	0 (0)	4 (5)	1 (1)
Edema	1 (1)	0 (0)	0 (1)	0 (0)	0 (1)	0 (0)	1 (1)	0 (0)
Generalized Weakness	0 (0)	0 (0)	0 (0)	0 (0)	1 (1)	0 (0)	1 (4)	0 (0)
Skin Disorders
Alopecia or nail disorder	1 (2)	0 (0)	1 (1)	0 (0)	0 (1)	0 (0)	2 (3)	0 (0)
Rash, Urticaria, pruritus	3 (3)	1 (1)	0 (1)	0 (0)	1 (1)	0 (0)	0 (1)	0 (0)
Respiratory
Cough	2 (3)	0 (0)	1 (1)	0 (0)	0 (1)	0 (0)	1 (5)	0 (0)
Dyspnea	2 (1)	0 (1)	0 (0)	0 (0)	0 (0)	0 (0)	1 (4)	0 (0)
Nasal congestion	0 (2)	0 (0)	0 (0)	0 (0)	0 (1)	0 (0)	0 (1)	0 (0)
Gastrointestinal
Nausea & Vomiting	1 (1)	0 (0)	1 (1)	0 (0)	1(1)	1(1)	0 (1)	0 (0)
Diarrhea	2 (3)	0 (0)	1 (2)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
Metabolism and Nutrition
Anorexia	0 (1)	0 (0)	0 (0)	0 (0)	0 (1)	0 (0)	0 (0)	0 (0)
Nervous System
Dizziness	0 (1)	0 (0)	0 (1)	0 (0)	0 (0)	0 (1)	0 (0)	1 (1)

Abbreviations: G1 = grade 1, G2 = grade 2, G3 = grade 3, G4 = grade 4