Table 3.
Regional cortical thickness of infants at high genetic risk for schizophrenia and control infants
| Regions | Thickness (mm)
|
Difference (%) | p values | |||
|---|---|---|---|---|---|---|
| Control infants
|
High-risk infants
|
|||||
| Least squares mean | SE | Least squares mean | SE | |||
| Frontal lobe | ||||||
| Superior frontal left | 2.06 | 0.02 | 2.06 | 0.03 | 0.14 | 0.9376 |
| Superior frontal right | 2.02 | 0.02 | 2.01 | 0.02 | −0.64 | 0.6900 |
| Rostral middle frontal left | 1.98 | 0.03 | 2.01 | 0.03 | 1.13 | 0.5784 |
| Rostral middle frontal right | 1.94 | 0.02 | 1.96 | 0.02 | 1.34 | 0.4023 |
| Caudal middle frontal left | 1.90 | 0.02 | 1.90 | 0.02 | −0.32 | 0.8476 |
| Caudal middle frontal right | 1.90 | 0.02 | 1.87 | 0.03 | −1.44 | 0.4469 |
| Pars opercularis left | 1.99 | 0.02 | 1.95 | 0.02 | −2.02 | 0.1300 |
| Pars opercularis right | 1.93 | 0.02 | 1.90 | 0.02 | −1.57 | 0.2585 |
| Pars triangularis left | 2.07 | 0.03 | 2.06 | 0.04 | −0.38 | 0.8705 |
| Pars triangularis right | 1.88 | 0.02 | 1.93 | 0.03 | 2.62 | 0.1820 |
| Pars orbitalis left | 2.06 | 0.03 | 2.08 | 0.04 | 0.73 | 0.7534 |
| Pars orbitalis right | 1.96 | 0.04 | 2.02 | 0.04 | 3.14 | 0.2566 |
| Lateral orbital frontal left | 1.93 | 0.02 | 1.94 | 0.02 | 0.42 | 0.7621 |
| Lateral orbital frontal right | 1.87 | 0.02 | 1.88 | 0.02 | 0.31 | 0.7990 |
| Medial orbital frontal left | 2.19 | 0.03 | 2.20 | 0.03 | 0.39 | 0.8336 |
| Medial orbital frontal right | 2.15 | 0.02 | 2.20 | 0.03 | 2.33 | 0.1851 |
| Frontal pole left | 2.21 | 0.08 | 2.45 | 0.09 | 10.70 | 0.0479* |
| Frontal pole right | 2.17 | 0.06 | 2.29 | 0.06 | 5.39 | 0.1710 |
| Precentral left | 1.97 | 0.02 | 1.96 | 0.02 | −0.88 | 0.5362 |
| Precentral right | 1.93 | 0.02 | 1.90 | 0.02 | −1.77 | 0.1798 |
| Paracentral left | 2.05 | 0.02 | 2.00 | 0.03 | −2.06 | 0.2532 |
| Paracentral right | 1.98 | 0.02 | 1.90 | 0.02 | −3.86 | 0.0168* |
| Parietal lobe | ||||||
| Postcentral left | 1.96 | 0.02 | 1.96 | 0.02 | 0.08 | 0.9600 |
| Postcentral right | 1.89 | 0.02 | 1.85 | 0.02 | −2.06 | 0.1370 |
| Supramarginal left | 1.98 | 0.02 | 1.98 | 0.02 | 0.09 | 0.9579 |
| Supramarginal right | 1.93 | 0.02 | 1.90 | 0.02 | −1.49 | 0.2690 |
| Superior parietal left | 1.88 | 0.02 | 1.87 | 0.02 | −0.57 | 0.6803 |
| Superior parietal right | 1.88 | 0.02 | 1.86 | 0.02 | −1.34 | 0.3089 |
| Inferior parietal left | 1.95 | 0.02 | 1.95 | 0.02 | 0.11 | 0.9360 |
| Inferior parietal right | 1.92 | 0.02 | 1.90 | 0.02 | −1.13 | 0.3990 |
| Precuneus left | 1.99 | 0.01 | 1.97 | 0.02 | −0.72 | 0.5014 |
| Precuneus right | 1.98 | 0.02 | 1.97 | 0.02 | −0.70 | 0.5757 |
| Temporal lobe | ||||||
| Superior temporal left | 2.06 | 0.02 | 2.06 | 0.02 | 0.27 | 0.8563 |
| Superior temporal right | 2.00 | 0.02 | 1.98 | 0.02 | −1.01 | 0.4259 |
| Middle temporal left | 1.98 | 0.02 | 1.95 | 0.02 | −1.51 | 0.3283 |
| Middle temporal right | 1.92 | 0.02 | 1.91 | 0.03 | −0.81 | 0.6569 |
| Inferior temporal left | 1.94 | 0.02 | 1.87 | 0.03 | −3.70 | 0.0516 |
| Inferior temporal right | 1.89 | 0.02 | 1.84 | 0.02 | −2.63 | 0.1003 |
| Transverse temporal left | 2.12 | 0.03 | 2.00 | 0.03 | −5.28 | 0.0088* |
| Transverse temporal right | 2.16 | 0.04 | 2.12 | 0.04 | −1.61 | 0.5157 |
| Banks superior temporal sulcus left | 1.98 | 0.02 | 1.90 | 0.03 | −4.03 | 0.0354* |
| Banks superior temporal sulcus right | 2.00 | 0.03 | 1.94 | 0.03 | −3.12 | 0.1330 |
| Entorhinal left | 2.09 | 0.05 | 2.08 | 0.06 | −0.59 | 0.8799 |
| Entorhinal right | 2.34 | 0.07 | 2.35 | 0.07 | 0.32 | 0.9401 |
| Parahippocampal Left | 1.66 | 0.03 | 1.71 | 0.03 | 2.97 | 0.2249 |
| Parahippocampal Right | 1.70 | 0.03 | 1.66 | 0.03 | −2.32 | 0.3178 |
| Temporal pole left | 2.55 | 0.05 | 2.59 | 0.05 | 1.35 | 0.6387 |
| Temporal pole right | 2.51 | 0.04 | 2.38 | 0.05 | −5.27 | 0.0416* |
| Fusiform left | 1.74 | 0.02 | 1.70 | 0.02 | −2.01 | 0.1297 |
| Fusiform right | 1.73 | 0.02 | 1.69 | 0.02 | −2.22 | 0.1750 |
| Occipital lobe | ||||||
| Lingual left | 1.87 | 0.02 | 1.78 | 0.03 | −4.60 | 0.0187* |
| Lingual right | 1.88 | 0.03 | 1.83 | 0.03 | −2.90 | 0.1587 |
| Pericalcarine left | 2.07 | 0.05 | 2.13 | 0.06 | 2.71 | 0.4871 |
| Pericalcarine right | 2.01 | 0.04 | 1.91 | 0.05 | −4.99 | 0.1185 |
| Cuneus left | 2.16 | 0.04 | 2.24 | 0.05 | 4.03 | 0.1731 |
| Cuneus right | 2.08 | 0.03 | 2.07 | 0.03 | −0.74 | 0.6998 |
| Lateral occipital left | 1.83 | 0.02 | 1.83 | 0.02 | −0.20 | 0.8978 |
| Lateral occipital right | 1.84 | 0.02 | 1.78 | 0.02 | −3.16 | 0.0143* |
| Cingulate cortex | ||||||
| Rostral anterior cingulate left | 2.23 | 0.05 | 2.23 | 0.05 | −0.22 | 0.9424 |
| Rostral anterior cingulate right | 2.25 | 0.04 | 2.22 | 0.05 | −1.54 | 0.5810 |
| Caudal anterior cingulate left | 2.11 | 0.03 | 2.10 | 0.04 | −0.18 | 0.9375 |
| Caudal anterior cingulate right | 2.10 | 0.03 | 2.09 | 0.04 | −0.64 | 0.7932 |
| Posterior cingulate left | 2.05 | 0.02 | 2.06 | 0.03 | 0.66 | 0.6983 |
| Posterior cingulate right | 2.11 | 0.02 | 2.04 | 0.02 | −2.95 | 0.0414* |
| Isthmus cingulate left | 2.06 | 0.03 | 2.08 | 0.04 | 1.05 | 0.6512 |
| Isthmus cingulate right | 2.04 | 0.03 | 2.09 | 0.04 | 2.62 | 0.2606 |
| Insula cortex | ||||||
| Insula left | 2.03 | 0.02 | 1.98 | 0.02 | −2.28 | 0.0996 |
| Insula right | 2.04 | 0.02 | 2.02 | 0.02 | −1.01 | 0.4284 |
*
p < 0.05