Skip to main content
. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: Clin Cancer Res. 2015 Feb 27;21(11):2624–2634. doi: 10.1158/1078-0432.CCR-14-2667

Figure 3. BRAF-inhibition induced cutaneous squamous cell carcinoma latency by UV-radiation exposure and histopathology.

Figure 3

Time course of lesion development is multifactorial and statistically related to ultraviolet radiation exposure and is associated with characteristic histopathology. Box-whisker plot with median (black horizontal line), 25th and 75th percentile (box) and min and max (whiskers). All cSCC samples for vemurafenib treated patients are shown (circles) by histomorphologic subtype and presence (+) or absence (–) of ultraviolet (UV) radiation exposure. *Significant 14.0 week decrease in latency in conventional type cSCC with UV radiation exposure (p-value = 0.016). **Significant 11.6 week decrease in latency in cSCC-WF ver. conv.-cSCC when matched for gender and UV-exposure in a multivariate model (p-value = 0.030).