Table 2.
Multivariable* Relative Risks of Postmenopausal Breast Cancer by AR Status According to Body Mass Index and Weight Change in the Nurses’ Health Study (1980–2006).
| Overall invasive breast cancer (n=5,953) |
NOT accounting for ER/PR status | Accounting for ER/PR status | |||||
|---|---|---|---|---|---|---|---|
| AR+ (n=1,701) | AR− (n=497) | P-het† | AR+ (n=1,701) | AR− (n=497) | P-het† | ||
| BMI (kg/m2) | |||||||
| <23 | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | ||
| 23–<25 | 1.09 (1.01, 1.18) | 0.96 (0.83, 1.10) | 1.34 (1.03,1.75) | 0.98 (0.85, 1.14) | 1.39 (1.02,1.88) | ||
| 25–<27.5 | 1.18 (1.09, 1.27) | 1.10 (0.95, 1.26) | 1.20 (0.91,1.58) | 1.09 (0.95, 1.26) | 1.29 (0.95,1.75) | ||
| 27.5–<30 | 1.34 (1.23, 1.46) | 1.15 (0.98, 1.35) | 1.68 (1.26,2.26) | 1.13 (0.96, 1.33) | 1.55 (1.11,2.17) | ||
| ≥ 30 | 1.47 (1.35, 1.59) | 1.20 (1.03, 1.40) | 1.54 (1.15, 2.06) | 0.14 | 1.17 (1.00, 1.37) | 1.64 (1.21,2.24) | 0.05 |
| p-trend | <0.0001 | 0.003 | 0.01 | 0.12 | 0.09 | ||
| Per 5 kg/m2increment | 1.16 (1.13,1.20) | 1.09 (1.03,1.15) | 1.14 (1.03,1.27) | 0.47 | 1.07 (1.01, 1.13) | 1.16 (1.05, 1.29) | 0.17 |
| Weight change since age 18 y, kg | |||||||
| Loss | |||||||
| ≥ 5.0 | 0.80 (0.66, 0.97) | 0.98 (0.70, 1.36) | 1.40 (0.74, 2.64) | 0.96 (0.68, 1.34) | 0.99 (0.47, 2.09) | ||
| 2.0–<5 | 1.05 (0.87, 1.26) | 0.95 (0.68, 1.34) | 1.88 (1.04, 3.38) | 0.87 (0.60, 1.25) | 1.59 (0.81, 3.11) | ||
| Loss or gain <2.0 | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | 1 (ref.) | ||
| Gain | |||||||
| 2.0–<10 | 1.19 (1.05, 1.34) | 1.10 (0.89, 1.35) | 1.50 (0.97, 2.33) | 1.10 (0.89, 1.38) | 1.29 (0.79, 2.11) | ||
| 10–<20 | 1.23 (1.10, 1.39) | 1.14 (0.93, 1.41) | 1.57 (1.01, 2.42) | 1.12 (0.90, 1.40) | 1.44 (0.89, 2.33) | ||
| ≥ 20 | 1.48 (1.31, 1.66) | 1.24 (1.00, 1.54) | 1.76 (1.12, 2.75) | 0.17 | 1.23 (0.98, 1.53) | 1.59 (0.98, 2.60) | 0.34 |
| Per 5 kg change | 1.06 (1.05, 1.08) | 1.04 (1.02,1.06) | 1.04 (1.00,1.08) | >0.99 | 1.04 (1.01,1.06) | 1.05 (1.01,1.10) | 0.52 |
*
MV-Adjusted for age at menarche, body mass index at age 18 years, height, parity and age at first birth, alcohol intake, postmenopausal hormone use, age at menopause, family history of breast cancer, and history of benign breast disease. There were 5,191 overall invasive breast tumors, 1,520 AR+, and 446 AR− tumors for weight change analyses.
†
p-values for heterogeneity between AR+ and AR− tumors.