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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Neuropharmacology. 2014 Dec 2;96(0 0):213–222. doi: 10.1016/j.neuropharm.2014.11.019

Figure 3. The MHb-IPN α5 and β4 nAChRs subunits mediate nicotine aversion.

Figure 3

(A) α5−/− mice self-administer more nicotine than wildtype mice. Data are presented as mean (± SEM) number of nicotine infusions earned across different nicotine doses. Modified with permission from (Fowler et al., 2011) (B) Total nicotine intake at each dose analyzed in A. Modified with permission from (Fowler et al., 2011). (C) Tabac mice, which overexpress β4 in the MHb, display strong aversion to nicotine in the two-bottle choice paradigm at increasing concentrations of nicotine. Data is expressed as percent of the volume of nicotine solution consumed divided by the total fluid intake per day. Modified with permission from (Frahm et al., 2011). (D) Tabac mice stereotactically injected in the MHb with a lentivirus encoding the most frequent variant associated to heavy smoking, α5 D398N, do not display nicotine aversion at 25 μg/ml in the two-bottle choice paradigm compared to Tabac mice injected with control lentivirus. Data is expressed as percent of the volume of nicotine solution consumed divided by the total fluid intake per day. Two-way ANOVA, p<0.05 Modified with permission from (Frahm et al., 2011).