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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Mol Psychiatry. 2014 Dec 2;20(11):1467–1478. doi: 10.1038/mp.2014.156

Table 3.

Significant Rare Variant Association Results Using Weighted Sum Statistic (WSS) in AA and EA Samples

Gene AA Sample EA Sample
SNPs Permuted p value SNPs Permuted p value
NRXN1 rs77665267 (p.T274P)
- (p.R206L)
- (p.Y367*)
- (p.S62*)		 2.28×10−4 rs77665267 (p.T274P)
- (p.R206L) 		2×10−6
CHRNA9 rs142807401 (p.A432T)
rs139982841 (p.A452V) 		3.81×10−4 rs56210055 (p.A312T)
rs142807401 (p.A432T)
rs139982841 (p.A452V) 		8×10−6
TAS2R38 rs139843932 (p.W135G)
rs114288846 (p.R274C) 		0.5346 rs139843932 (p.W135G)
rs114288846 (p.R274C) 		2×10−6†
CHRNA2 - (p.S488*)
- (p.R121L)		 1.31×10−4 N/A N/A
NTRK2 rs150692457 (p.L140F)
- (p.C623*)		 4.25×10−4 N/A N/A
GABBR2 - (p.P742Q)
- (p.G671C)		 1.58×10−4 N/A N/A
GRIN3A rs75981117 (p.N549S)
rs34755188 (p.R480H)
- (p.V389L)
- (p.V132L) 		2.42×10−3 rs75981117 (p.N549S)
rs34755188 (p.R480H)
- (p.V389L)
- (p.V132L) 		8×10−6
DNM1 rs61757224 (p.L16M)
- (p.S126*)
- (p.R228L)
- (p.Y231*)		 3.53×10−4 N/A N/A
DBH rs182974707 (p.I340T)
rs75215331 (p.A362V)
- (p.Y389*)
- (p.T395P)
rs41316996 (p.G482R)
rs6271 (p.R549C)		 0.2427 rs182974707 (p.I340T)
rs75215331 (p.A362V)
rs41316996 (p.G482R) 		1×10−6
NRXN2 - (p.T1371P)
- (p.V53G)
- (p.E267G)		 1.49×10−3 N/A N/A
ANKK1/DRD2 rs35877321 (p.R122H)
rs56047699 (p.R237*)
- (p.S313*)
rs186633697 (p.P351S)
rs56299709 (p.E376K)
rs184645039 (p.E458G)
rs113005509 (p.E587*)
rs202222056 (p.Q657*)
- (p.R734C)
- (p.E181*) 		0.8114 rs111789052 (p.C52W)
rs35877321 (p.R122H)
rs115800217 (p.R185Q)
rs56047699 (p.R237*)
- (p.S313*)
rs56299709 (p.E376K)
rs78229381 (p.R445C)
rs184645039 (p.E458G)
rs113005509 (p.E587*)
- (p.R734C)
- (p.E181*) 		6×10−6
NRXN3 rs199840331 (p.Y234*)
- (p.G696*)
- (p.T99P) 		2.17×10−4 - (p.G696*)
- (p.T99P) 		1×10−6†
CDH13 rs72807847 (p.N39S)
rs200591230 (p.V464I) 		0.5231 rs72807847 (p.N39S)
rs200591230 (p.V464I) 		3.5×10−5†
ARRB2 - (p.T84P)
- (p.H281Q)		 1.32×10−4 N/A N/A
†

P value based on 108 permutations.

Notes:

1) Permuted p value = value based on 106 permutations; - = not reported in dbSNP database by 2/17/2014; N/A = not applicable; i.e., without two rare nonsynonymous variants in gene or region.

2) SNPs included in both AA and EA rare variant analysis are underlined.

3) Significant association p values after correction for multiple testing(p< 2.63×10−3 for AA sample and p< 4.55×10−3 for EA sample) are given in bold. See “Materials and Methods” for details.