Figure 3. Network diagrams for Group1 gene coexpression modules associated with lifetime alcohol consumption.

Visualization demonstrates the inter-connection of genes for the top ten percent of module members with ≥ |r = 0.80| correlation strength. Relative size of the depicted networks is based upon the size of the four modules. Size of the nodes reflects the module connectivity ranking for individual genes. The degree of node opacity is proportional to the correlation with lifetime consumption, with alcohol hubs defined as those genes within the top ten percent of alcohol-associated genes in our human sample. Networks were further overlapped using a prior meta-analysis of alcohol drinking behavior in mice⁴⁵ to identify potential points of convergent validity in rodent models.