Table 2.

Aggressive MDSCs in EAE.

	Species	Diseases or models	Cell surface phenotype	Mechanism of suppression	Reference
1	Mouse	EAE	CD11b+ CD62L Ly-6Chi	Maturation into functional DCs and/or inflammatory macrophages	[50]
2	Mouse	EAE	CD11b+Gr1+	Th17, IL-1	[52]
3	Mouse	EAE	CD11b+Ly-6ChiLy-6G−/low	(i) Induction of MDSC apoptosis; (ii) polarization of MDSCs to mature subsets of myeloid cells (dendritic cells/macrophages/neutrophils); and (iii) altering their immunosuppressor phenotype	[56]