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MDSCs-mediated refractoriness to chemotherapy or radiotherapy.
| Treatment | Mechanisms | References |
|---|---|---|
| Anti-VEGF antibody (bevacizumab) | Bv8 production in MDSCs | [118] |
|
| ||
| Anthracycline/cyclophosphamide | S100A8/9 production in accumulated MDSCs via secretion of CXCL1/2 by cancer cells | [8] |
|
| ||
| Tyrosine kinase inhibitor (sunitinib) | Bv8 production in MDSCs pSTAT5-dependent pathway via GM-CSF production |
[118, 119] |
|
| ||
| Radiotherapy | G-CSF-mediated MDSC accumulation | [120] |
