Skip to main content
. 2015 Jun 3;35(22):8593–8603. doi: 10.1523/JNEUROSCI.3993-14.2015

Figure 1.

Figure 1.

NGF-induced persistent thermal and mechanical allodynia require protein synthesis and are mediated by TRPV1 and oxidation. Blinded observers measured thermal (A) and mechanical hindpaw thresholds (B) for 2 weeks in NGF- (30 μg/kg/d × 5 d) or vehicle (n = 6/group)-treated rats. Data were analyzed by repeated-measures ANOVA with Tukey's post hoc test. Error bars are SEM. *p < 0.05, **p < 0.01, ***p < 0.001. Blinded observers measured thermal (C) and mechanical (D) thresholds in NGF-treated rats on day 8 after coadministration of anisomycin (50 mg/kg, s.c.), cycloheximide (1 mg/kg, s.c.), or vehicle with NGF during days 1–5 or after CPZ (100 mg/kg, s.c.), NDGA (40 mg/kg, s.c.), NAC (50 mg/kg, s.c.), or vehicle injection on day 8 (n = 6–10/group). Data were analyzed by ANOVA with Tukey's post hoc test. Error bars are SEM. *p < 0.05, ***p < 0.001 compared with baseline; ##p < 0.01, ###p < 0.001 compared with vehicle; ∧∧p < 0.01, ∧∧∧p < 0.001 compared with NAC.