Skip to main content
. 2015 Jun 3;35(22):8593–8603. doi: 10.1523/JNEUROSCI.3993-14.2015

Figure 2.

Figure 2.

Persistent NGF-evoked thermal hyperalgesia and mechanical allodynia are mediated by spatially distinct mechanisms. Blinded observers measured thermal (A) and mechanical (B) thresholds in NGF-treated rats on day 8 after hindpaw injections of NDGA (0.5, 5, or 50 μg, i.pl.), CPZ (10, 100, or 1000 μg, i.pl.), or vehicle (n = 5–6/group). Blinded observers measured thermal (C) and mechanical (D) thresholds in NGF-treated rats on day 8 after spinal cord injections of NDGA (5 μg, i.t.), CPZ (100 μg, i.t.), or vehicle (n = 5–6/group). Data were analyzed by ANOVA with Tukey's post hoc test. Error bars are SEM. ***p < 0.001 compared with baseline, ##p < 0.01, ###p < 0.001 compared with vehicle. Blinded observers measured thermal (E) and mechanical (F) thresholds in NGF-treated rats on day 8 after hindpaw injections of BEL (0.3, 3, or 30 μg, i.pl.) or vehicle (n = 6–7/group). Blinded observers measured thermal (G) and mechanical (H) thresholds in NGF-treated rats on day 8 after spinal cord injections of BEL (0.3, 3, or 30 μg, i.t.) or vehicle (n = 6–7/group). Data were analyzed by ANOVA with Tukey's post hoc test. Error bars are SEM. ***p < 0.001 compared with baseline; ###p < 0.001 compared with vehicle; ∧p < 0.05, ∧∧p < 0.01, ∧∧∧p < 0.001 compared with 0.3 μg BEL.