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. 2015 Jun 1;10(6):e0128232. doi: 10.1371/journal.pone.0128232

Table 2. Subgroup Analyses of the Association between Opioid Use and Fracture Risk.

Factor No. of studies RR (95% CI) Heterogeneity P (I2%)
Study design Retrospective cohort 2 2.95 (1.12–7.78) 0.000 (96.4)
Prospective cohort 6 1.62 (1.31–2.02) 0.003 (72.5)
Region Europe 3 1.68 (1.30–2.17) 0.690 (0.0)
USA 5 1.97 (1.49–2.61) 0.000 (91.4)
Fracture type hip fracture 3 2.03 (1.86–2.22) 0.615 (0.0)
any fracture 5 1.88 (1.51–2.34) 0.000 (91.0)