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. 2014 Dec 5;4:66. doi: 10.1186/s13550-014-0066-y

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© Ridler et al.; licensee Springer. 2014

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.

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[ ¹¹ C]GSK1034702 in Subject 4 in the human brain. Tracer [¹¹C]GSK1034702 PET data - integral images 0-120 min in subject 4. Post dose 5 mg of GSK1034702 [¹¹C]GSK1034702 PET data - integral images 0-120 min in subject 4. K ₁ = rate constant for transfer from arterial plasma to tissue (mL.cm⁻³.min⁻¹). V _T = volume of distribution (mL.cm⁻³). Regions of interest: MTL = medial temporal lobe (ROI defined above), cerebellum, thalamus and striatum and cortex = sum of cortical regions (includes grey and white matter); white matter = all cerebral white matter.