Table 3.
Regional V T , K 1 values and GSK1034702 injected mass (μg) and [ 11 C]GSK1034702 injected dose in MBq for each scan in the human brain
| ROI | Subject 1 | Subject 2 | Subject 4 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Scan 1 (baseline) | Scan 1 (baseline) | Scan 2 (post dose) | Scan 1(baseline) | Scan 2 (post dose) | ||||||
| K 1 | V T | K 1 | V T | K 1 | V T | K 1 | V T | K 1 | V T | |
| MTL | 0.33 | 7.81 | 0.19 | 13.3 | 0.16 | 8.30 | 0.24 | 7.11 | 0.25 | 6.91 |
| Cerebellum | 0.23 | 5.33 | 0.19 | 4.75 | 0.15 | 3.69 | 0.19 | 5.17 | 0.19 | 4.56 |
| White matter | 0.13 | 4.63 | 0.10 | 4.38 | 0.08 | 4.01 | 0.11 | 5.04 | 0.11 | 4.49 |
| Cortex | 0.19 | 5.37 | 0.16 | 5.00 | 0.12 | 4.03 | 0.16 | 5.57 | 0.17 | 4.81 |
| Striatum | 0.20 | 5.59 | 0.16 | 5.05 | 0.13 | 5.29 | 0.18 | 5.83 | 0.18 | 4.93 |
| Thalamus | 0.29 | 6.29 | 0.19 | 5.44 | 0.15 | 4.39 | 0.20 | 5.74 | 0.20 | 5.11 |
| GSK1034702 injected mass | 38.48 | 34.17 | 49.35 | 46.02 | 44.19 | |||||
| [11C]GSK1034702 injected dose | 284.19 | 322.12 | 263.02 | 300.50 | 325.50 | |||||
Regions of interest: MTL = medial temporal lobe (ROI defined above), cerebellum, thalamus and striatum and cortex = sum of cortical regions (includes grey and white matter); white matter = all cerebral white matter. K 1 = rate constant for transfer from arterial plasma to tissue (mL.cm−3.min−1). V T = volume of distribution (mL.cm−3). GSK1034702 injected mass in microgrammes. [11C]GSK1034702 injected dose in megabecquerel.