Table 3.

Average bias (%) for all parameters derived from simulated tissue TACs of all three simulated tissues

	Noise	K 1 1T2k	V T 1T2k	K 1 2T3k	K i 2T3k	K 1 2T4k	V T 2T4k
Healthy	0%	−26.37	−22.01	−19.00	21.51	0.00	0.00
	1%	−26.54	−21.58	−18.99	21.52	0.01	0.31
	5%	−26.47	−20.97	−18.43	22.36	0.47	7.41
	10%	−26.37	−18.03	−15.01	27.49	3.76	14.49
	20%	−26.17	−10.74	−6.73	39.91	8.23	15.56
Scar	0%	−22.07	−11.97	−15.27	41.21	0.00	0.00
	1%	−22.26	−11.88	−15.26	41.23	0.00	0.20
	5%	−22.26	−11.78	−15.21	41.32	0.57	14.19
	10%	−22.32	−10.73	−14.50	42.50	3.12	95.17
	20%	−21.79	−8.99	−11.65	47.25	14.08	208.98
Denervated	0%	−29.56	−12.35	−20.71	58.59	0.00	0.00
	1%	−29.79	−12.35	−20.68	58.63	0.03	0.02
	5%	−29.74	−12.19	−20.72	58.56	0.28	1.24
	10%	−29.68	−12.13	−20.39	59.22	0.38	18.55
	20%	−29.52	−10.95	−18.95	62.10	4.33	82.07

Bias was calculated by comparing the obtained values of K ₁, V _T and K _i with those used in the 2T4k model to generate time-activity curves (i.e. the 2T4k model has no bias for 0% noise). Bias due to noise can be appreciated by comparing the obtained bias with those at 0% noise.