Table 1.
Biodistribution of 177 Lu-DOTA-chCE7 and 177 Lu-DOTA-control IgG 72 h post RIC injection in nude mice bearing subcutaneous IGROV1 tumours (±PTX)
| Organs | 177 Lu-DOTA-chCE7 | 177 Lu-DOTA-chCE7 + PTX | 177 Lu-DOTA-control IgG | 177 Lu-DOTA-control IgG + PTX |
|---|---|---|---|---|
| Blood | 8.9 ± 2.8 | 6.9 ± 3.5 | 17.12 ± 3.6 | 13.3 ± 8.5 |
| Heart | 3.9 ± 0.8 | 3.3 ± 1.4 | 5.7 ± 2.9 | 3.9 ± 1.7 |
| Spleen | 7.0 ± 2.3 | 5.7 ± 1.0 | 5.0 ± 2.8 | 10.2 ± 6.1 |
| Kidney | 2.8 ± 0.3 | 2.4 ± 0.6 | 5.4 ± 1.9 | 4.6 ± 1.8 |
| Stomach | 0.4 ± 0.2 | 0.4 ± 0.1 | 0.8 ± 0.8 | 1.0 ± 0.4 |
| Intestine | 0.8 ± 0.2 | 0.7 ± 0.3 | 1.1 ± 0.3 | 0.4 ± 0.5 |
| Liver | 5.3 ± 1.8 | 5.7 ± 0.3 | 5.7 ± 2.5 | 6.7 ± 1.2 |
| Muscle | 0.9 ± 0.2 | 0.8 ± 0.2 | 1.1 ± 0.3 | 1.4 ± 0.6 |
| Bone | 1.5 ± 0.2 | 1.1 ± 0.5 | 1.9 ± 0.6 | 2.6 ± 0.5 |
| Tumour | 49.6 ± 11.9 | 45.3 ± 8.6 | 7.2 ± 2.3 | 9.1 ± 3.1 |
Results shown in %IA/g ± SD.