Table 1.
Comparison of regional uptake and binding potential in the different brain regions
| Mouse | Rat | Guinea pig | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | CsA | P value | Baseline | CsA | P value | Baseline | CsA | P value | |
| %SUV | |||||||||
| Whole brain | 33.4 ± 2.4 | 98.6 ± 10.8 | 0.0000 | 37.4 ± 4.1 | 119.0 ± 29.3 | 0.0002 | 259.6 ± 34.6 | 643.1 ± 192.4 | 0.0020 |
| Cortex | 30.9 ± 2.6 | 95.1 ± 10.6 | 0.0000 | 38.7 ± 4.2 | 113.0 ± 26.7 | 0.0002 | 213.3 ± 27.3 | 566.9 ± 198.1 | 0.0027 |
| Striatum | 28.6 ± 2.4 | 110.4 ± 12.1 | 0.0000 | 37.0 ± 5.8 | 146.9 ± 43.5 | 0.0003 | 394.4 ± 58.7 | 768.3 ± 299.9 | 0.0205 |
| Thalamus | 29.3 ± 2.2 | 114.4 ± 14.1 | 0.0000 | 36.2 ± 5.3 | 145.5 ± 41.8 | 0.0003 | 301.5 ± 44.9 | 792.1 ± 216.4 | 0.0015 |
| Hypothalamus | 40.3 ± 2.3 | 107.8 ± 10.3 | 0.0000 | 41.2 ± 5.9 | 143.6 ± 39.7 | 0.0003 | 354.9 ± 60.9 | 794.3 ± 204.1 | 0.0019 |
| Hippocampus | 28.0 ± 2.2 | 102.6 ± 11.0 | 0.0000 | 35.6 ± 4.6 | 137.3 ± 40.1 | 0.0003 | 228.3 ± 31.7 | 605.7 ± 171.1 | 0.0011 |
| Central canal-PAG | 27.1 ± 1.8 | 106.3 ± 13.4 | 0.0000 | 37.4 ± 5.3 | 147.4 ± 38.7 | 0.0002 | 446.2 ± 71.8 | 986.5 ± 248.0 | 0.0027 |
| Colliculus inferior | 28.0 ± 2.6 | 107.1 ± 12.9 | 0.0000 | 36.7 ± 4.1 | 138.7 ± 38.0 | 0.0003 | 192.7 ± 30.3 | 900.5 ± 264.7 | 0.0005 |
| Colliculus superior | 28.1 ± 2.9 | 94.1 ± 10.2 | 0.0000 | 34.4 ± 4.3 | 127.9 ± 32.2 | 0.0002 | 428.4 ± 69.7 | 1 072.5 ± 291.8 | 0.0018 |
| Midbrain | 30.8 ± 2.4 | 111.5 ± 12.5 | 0.0000 | 37.4 ± 4.3 | 143.6 ± 36.7 | 0.0002 | 409.5 ± 67.6 | 970.1 ± 245.5 | 0.0018 |
| Cerebellum | 33.7 ± 3.1 | 81.1 ± 8.6 | 0.0000 | 34.0 ± 3.3 | 96.4 ± 18.3 | 0.0001 | 162.7 ± 24.8 | 467.5 ± 135.8 | 0.0006 |
| Cerebellum GM | - | - | - | - | - | - | 120.8 ± 17.4 | 372.6 ± 122.1 | 0.0009 |
| BPND | |||||||||
| Whole brain | - | 0.19 ± 0.04 | n/a | - | 0.21 ± 0.10 | n/a | 1.56 ± 0.39 | 1.57 ± 0.44 | n.s. |
| Cortex | - | 0.12 ± 0.04 | n/a | - | 0.15 ± 0.10 | n/a | 1.00 ± 0.23 | 1.23 ± 0.30 | n.s. |
| Striatum | - | 0.39 ± 0.08 | n/a | - | 0.48 ± 0.21 | n/a | 3.13 ± 0.90 | 2.36 ± 0.52 | 0.0224 |
| Thalamus | - | 0.39 ± 0.16 | n/a | - | 0.48 ± 0.18 | n/a | 2.05 ± 0.55 | 2.29 ± 0.72 | n.s. |
| Hypothalamus | - | 0.30 ± 0.06 | n/a | - | 0.45 ± 0.15 | n/a | 2.76 ± 0.74 | 2.81 ± 1.04 | n.s. |
| Hippocampus | - | 0.25 ± 0.11 | n/a | - | 0.39 ± 0.18 | n/a | 1.25 ± 0.29 | 1.38 ± 0.38 | n.s. |
| Central canal-PAG | - | 0.15 ± 0.17 | n/a | - | 0.50 ± 0.11 | n/a | 4.06 ± 1.36 | 5.00 ± 3.04 | n.s. |
| Colliculus inferior | - | 0.17 ± 0.19 | n/a | - | 0.42 ± 0.12 | n/a | 3.08 ± 0.86 | 4.00 ± 1.54 | n.s. |
| Colliculus superior | - | 0.13 ± 0.06 | n/a | - | 0.27 ± 0.14 | n/a | 3.50 ± 1.15 | 3.65 ± 1.11 | n.s. |
| Midbrain | - | 0.26 ± 0.20 | n/a | - | 0.46 ± 0.11 | n/a | 3.34 ± 1.01 | 3.40 ± 1.17 | n.s. |
| Cerebellum | - | - | - | - | - | - | 0.52 ± 0.16 | 0.49 ± 0.44 | n.s. |
Regional uptake and binding potential of [11C]AZ10419369 in the different brain regions in mice, rats, and guinea pigs during baseline and CsA pretreatment conditions (each value represents mean ± SD). n/a, not applicable; n.s., not significant.