Table 1.
Organ biodistribution of IG3
Control | 2 W-MI | 4 W-MI | |
---|---|---|---|
MI infarct (apex) | 0.058 ± 0.039 | 0.151 ± 0.047† | 0.071 ± 0.059 |
MI border | 0.047 ± 0.028 | 0.110 ± 0.021* | 0.056 ± 0.044 |
MI remote | 0.045 ± 0.033 | 0.108 ± 0.026* | 0.055 ± 0.044 |
Lung | 0.094 ± 0.034 | 0.194 ± 0.055 | 0.093 ± 0.073 |
Liver | 0.236 ± 0.249 | 0.519 ± 0.095 | 0.192 ± 0.198 |
Spleen | 0.079 ± 0.035 | 0.356 ± 0.041Φ | 0.134 ± 0.118 |
Kidney | 0.502 ± 0.101 | 0.784 ± 0.149 | 0.693 ± 0.367 |
Bone | 0.057 ± 0.025 | 0.070 ± 0.013 | 0.053 ± 0.034 |
Thyroid | 1.126 ± 1.409 | 1.326 ± 0.298 | 1.342 ± 0.223 |
Muscle | 0.015 ± 0.004 | 0.021 ± 0.001 | 0.022 ± 0.013 |
Data are presented as %ID/g (mean ± SD) 4 h after injection.
%ID/g, percent injected dose per gram; MI, myocardial infarction; 2 W-MI, myocardial infarction 2 weeks old; 4 W-MI, myocardial infarction 4 weeks old.
*p < 0.05 control vs. 2 W-MI rats.
† p < 0.01 control vs. 2 W-MI rats.
Φ p = 0.0571 2 W-MI vs. control and 2 W-MI vs. 4 W-MI rats.