Fig 3. HSV-1-induced cytochrome c release is mediated via Bax/Bak.
(A) Anti-cytochrome c, anti-active caspase-3 and Hoechst 33334 (nuclei) and (B) anti-COX-VIc (mitochondrial marker) and anti-cytochrome c immunofluorescence analyses of SV40 TAg WT and Bax/Bak-/- MEFs infected with 10 moi of HSV-1 for 18 h (hpi). Magnifications in (A) and (B) are 400 and 1000 fold, respectively.