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. 2015 Jun 2;10(6):e0129852. doi: 10.1371/journal.pone.0129852

Fig 2. An introduction to retinoblastoma genetics.

Fig 2

Retinoblastoma is initiated by loss-of-function of the tumor suppressor gene RB1 (RB1 -/-) in one eye (unilateral) or both eyes (bilateral). There are different implications for care for different scenarios. Notably, a rare cause of non-heritable retinoblastoma is unrelated to RB1, amplification of the gene MYCN.