Table 2. Ozone-induced cellular inflammation in airways.
| Cells Recovered in BAL | 0 ppb O3 | 100 ppb O3 | 200 ppb O3 | PE±SEM (x104 cells/ml per 100 ppb increase in O3) | p-value | |
|---|---|---|---|---|---|---|
| Leukocytes (x104 cells/ml) | 20.6±11.5 | 21.5±10.6 | 22.6±8.8 | 0.97±0.87 | 0.26 | |
| Macrophages (x104 cells/ml) | 17.3±10.0 | 17.6±10.0 | 18.1±6.9 | 0.40±0.83 | 0.63 | |
| Neutrophils (x104 cells/ml) | 0.55±0.56 | 0.94±0.91 | 1.51±1.79 | 0.48±0.20 | 0.01 | |
| Lymphocytes (x104 cells/ml) | 2.8±2.0 | 2.7±1.5 | 2.6±2.1 | -0.08±0.24 | 0.72 | |
| Eosinophils (x104 cells/ml) | 0.14±0.17 | 0.23±0.26 | 0.37±0.49 | 0.11±0.05 | 0.02 | |
| Epithelial Cells (x104 cells/ml) | 0.98±1.21 | 0.74±0.93 | 0.88±1.06 | -0.05±0.16 | 0.77 | |
| Squamous Cells (x104 cells/ml) | 0.33±0.26 | 0.18±0.18 | 0.26±0.28 | -0.03±0.04 | 0.43 | |
| RBC (x104 cells/ml) | 10.3±10.0 | 8.0±8.2 | 19.7±39.8 | 4.70±3.83 | 0.22 | |
Data presented as mean ± standard deviation (SD) and parameter estimate ± standard error of mean (PE±SEM) for linear regression models. N = 19; p-values are from the regression model of each BAL inflammatory cell against level of ozone exposure. O3: ozone; RBC: red blood cells. Significant comparisons are shown in bold.