Table 4. Enriched Gene Ontologies From Differentially Expressed Genes Across Ozone Exposures.
| Term | Gene Descriptors | FDR (%) | p-value |
|---|---|---|---|
| GO:0006952~defense response | S100A12, CCL22, LILRA1, CORO1A, CCL2, CCR2, CLEC5A, PLA2G7, CX3CR1, SPP1, IL8RA | 0.01 | 8.6 x 10–6 |
| GO:0006955~immune response | GPR183, CCL22, CD1E, LILRA1, CD1C, CORO1A, CCL2, IL1R2, CCR2, CLEC5A, IFITM2 | 0.03 | 2.4E x 10–5 |
| GO:0006935~chemotaxis | CCL22, CORO1A, CCL2, CCR2, CX3CR1, IL8RA | 0.1 | 1.0 x 10–4 |
| GO:0007626~locomotory behavior | CCL22, ANKH, CORO1A, CCL22, CCR2, CX3CR1, IL8RA | 0.2 | 1.4 x 10–4 |
| GO:0006954~inflammatory response | S100A12, CCL22, CCL2, CCR2, PLA2G7, SPP1, IL8RA | 0.5 | 3.5 x 10–4 |
| hsa04062:Chemokine signaling pathway | CCL22, CX3CR1, CCR2, PRKCB, CCL22, IL8RA | 0.5 | 6.3 x 10–4 |
| GO:0009611~response to wounding | S100A12, CCL22, CCL2, CCR2, PLA2G7, CX3CR1, SPP1, IL8RA | 1.2 | 8.2 x 10–4 |
| GO:0004950~chemokine receptor activity | CCR2, CX3CR1, IL8RA | 2.0 | 1.7 x 10–3 |
| GO:0016021~integral to membrane | ANKH, IL1R2, CLEC5A, MGAM, IFITM2, CD1E, LAMP3, SelectinL, PLXNC1, ACPP, SEMA4A, CHST15, CX3CR1, GPR183, MERTK, C4orf18, SELL, HSD11B1, | 2.4 | 2.2 x 10–3 |
| PIRSF038545:chemokine receptor | CCR2, CX3CR1, IL8RA | 2.5 | 2.8 x 10–3 |
| hsa04060:Cytokine-cytokine receptor interaction | CCL2, CCL22, IL1-R2, CCR2, CX3CR1, IL8RA | 2.6 | 2.9 x 10–3 |
| GO:0019955~cytokine binding | IL1-R2, CCR2, CX3CR1, IL8RA | 2.8 | 2.4 x 10–3 |
| GO:0005886~plasma membrane | S100A12, GPR183, MERTK, ANKH, CORO1A, SELL, PLA2G7, CCR2. CLEC5A, MGAM, PRKCB, IL8RA, KCNJ15, CD1E, LILRA1, CD1C, SelectinL, SIGLEC10 | 5.6 | 5.1 x 10–3 |
| IPR007110:Immunoglobulin-like | CD1E, MERTK, LILRA1, CD1C, IL1R2, SIGLEC10 | 9.1 | 8.2 x 10–3 |
| GO:0005887~integral to plasma membrane | GPR183, CD1E, MERTK, ANKH, CD1C, SELL, CCR2, CLEC5A, SelectinL, CX3CR1, KCNJ15 | 10.4 | 9.8 x 10–3 |
| IPR013151:Immunoglobulin | MERTK, LILRA1, IL1R2, SIGLEC10 | 15.4 | 1.4 x 10–2 |
| GO:0006968~cellular defense response | CCR2, CLEC5A, CX3CR1 | 17.9 | 1.4 x 10–2 |
| GO:0005615~extracellular space | CCL22, CCL2, PLA2G7, SULF2, MMP9, SPP1, MMP8 | 19.1 | 1.9 x 10–2 |
| GO:0015674~di-, tri-valent inorganic cation transport | CORO1A, STEAP4, PRKCB, SLC25A37 | 19.2 | 1.5 x 10–2 |
| GO:0007155~cell adhesion | CORO1A, CCL2, SELL, SIGLAC10, PLXNC1, CX3CR1, SPP1 | 20.3 | 1.6 x 10–2 |
Analysis using DAVID showed 20 enriched gene ontologies to be associated with the DEGs based on linear regression and pair-wise comparison (consistent across all 3 pairs) analyses with FDR threshold <25%.