Table 5. Enriched Gene Ontologies From Differentially Expressed Genes Across 0 and 200 ppb Ozone Exposure.
| Term | Gene Descriptors | FDR (%) | p-value |
|---|---|---|---|
| GO:0005615~extracellular space | IL8, CCL2/mcp-1, HTRA1, PLA2G7, SULF2, MMP9, SPP1, MMP8 | 0.3 | 2.5 x 10–4 |
| GO:0044421~extracellular region part | IL8, CCL2/mcp-1, HTRA1, PLA2G7, PI3, SULF2, MMP9, SPP1, MMP8 | 0.3 | 3.4 x 10–4 |
| hsa04060:Cytokine-cytokine receptor interaction | IL8, CCL2/mcp-1, IL1R2/CD121b, HGF, CX3CR1, IL8RA/CXCR1/CD181 | 0.4 | 4.8 x 10–4 |
| GO:0006954~inflammatory response | S100A12, IL8, CCL2/mcp-1, PLA2G7, SPP1, IL8RA/CXCR1/CD181 | 0.4 | 2. x 10–4 |
| GO:0009611~response to wounding | S100A12, IL8, CCL2/mcp-1, PLA2G7, CX3CR1, SPP1, IL8RA/CXCR1/CD181 | 0.5 | 3.3 x 10–4 |
| GO:0006952~defense response | S100A12, IL8, CCL2/mcp-1, PLA2G7, CX3CR1, SPP1, IL8RA/CXCR1/CD181 | 1.0 | 7.3 x 10–4 |
| GO:0005576~extracellular region | IL8, SPINK1, CCL2/mcp-1, HTRA1, HGF, PLA2G7, PI3, SULF2, MMP9, SPP1, MMP8 | 3.1 | 3.0 x 10–3 |
| GO:0006935~chemotaxis | IL8, CCL2/mcp-1, CX3CR1, IL8RA/CXCR1/CD181 | 4.1 | 3.1 x 10–3 |
| GO:0042330~taxis | IL8, CCL2/mcp-1, CX3CR1, IL8RA/CXCR1/CD181 | 4.1 | 3.1 x 10–3 |
| hsa04062:Chemokine signaling pathway | IL8, CCL2/mcp-1, CX3CR1, IL8RA/CXCR1/CD181 | 10.0 | 1.3 x 10–2 |
| GO:0006955~immune response | IL8, GPR183, CD1E, CD1C, CCL2/mcp-1, IL1R2/CD121b | 10.1 | 7.7 x 10–3 |
| GO:0019955~cytokine binding | IL1R2/CD121b, CS3CR1, IL8RA/CXCR1/CD181 | 15.3 | 1.4 x 10–2 |
| hsa04640:Hematopoietic cell lineage | CD1E, CD1C, IL1R2/CD121b | 16.5 | 2.3 x 10–2 |
| GO:0007626~locomotory behavior | IL8, CCL2/mcp-1, CX3CR1, IL8RA/CXCR1/CD181 | 17.1 | 1.3 x 10–2 |
| GO:0004175~endopeptidase activity | HTRA1, HGF, MMP9, MMP8 | 24.6 | 2.4 x 10–2 |
Analysis using DAVID showed 15 enriched gene ontologies to be associated with the DEGs based on pair-wise comparison between 0 and 200 ppb ozone exposure with FDR threshold <25%.