Table 6. Gene Set Analysis (GSA) Using Ingenuity Pathway Analysis (IPA).

Set Name	GSA Score	GSA p-value	GSA FDR (%)
KEGG_HEMATOPOIETIC_CELL_LINEAGE	0.634	<0.001	<0.1
BIOCARTA_CALCINEURIN_PATHWAY	0.688	<0.001	<0.1
BIOCARTA_CCR5_PATHWAY	0.857	<0.001	<0.1
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION	0.385	<0.001	<0.1
G_PROTEIN_COUPLED_RECEPTOR_BINDING	0.667	<0.001	<0.1
METALLOPEPTIDASE_ACTIVITY	0.457	<0.001	<0.1
CHEMOKINE_ACTIVITY	0.684	<0.001	<0.1
CHEMOKINE_RECEPTOR_BINDING	0.787	<0.001	<0.1
METALLOENDOPEPTIDASE_ACTIVITY	0.647	<0.001	<0.1
BEHAVIOR	0.499	<0.001	<0.1
LOCOMOTORY_BEHAVIOR	0.690	<0.001	<0.1
INFLAMMATORY_RESPONSE	0.422	<0.001	<0.1
RESPONSE_TO_EXTERNAL_STIMULUS	0.352	<0.001	<0.1
RESPONSE_TO_WOUNDING	0.415	<0.001	<0.1
KEGG_ALDOSTERONE_REGULATED_SODIUM_REABSORPTION	0.483	0.002	4.5
BIOCARTA_CARDIACEGF_PATHWAY	0.651	0.002	4.5
KEGG_CHEMOKINE_SIGNALING_PATHWAY	0.287	0.002	4.5

GSA identified 17 processes associated with the DEGs from linear regression analysis with FDR threshold <5%.