Table 2. Univariate ORs for mclx2 and mclx3 pseudogenization (p values <0.2 are highlighted).

			univariate ORs (95% CI)
independent variables		n	mclx2 pseudogenization	mclx3 pseudogenization
patient-related
age		126	0.973 (0.942–1.006); p = 0.103	1.008 (0.983–1.033); p = 0.553
gender			p = 0.624	p = 0.061
	female	47	1.255 (0.507–3.106)	2.202 (0.965–5.024)
	male	79	1 (ref)	1 (ref)
birth region			p = 0.589	p = 0.005
	Africa	23	0.679 (0.216–2.137); p = 0.508	0.000 (0.000-.); p = 0.998
	The Americas	12	0.385 (0.073–2.022); p = 0.259	0.886 (0.158–4.974); p = 0.890
	Eastern Mediterranean	23	0.288 (0.072–1.154); p = 0.079	0.664 (0.154–2.874); p = 0.584
	Europe	38	1 (ref)	1 (ref)
	South East Asia	17	0.000 (0.000-.); p = 0.998	3.100 (0.873–11.007); p = 0.080
	Western Pacific	13	0.000 (0.000-.); p = 0.999	53.143 (5.896–478.992); p<0.001
ethnicity			p = 0.002	p = 0.391
	native dutch	28	4.583 (1.738–12.088)	0.626 (0.215–1.823)
	foreign-born	97	1 (ref)	1 (ref)
house setting			p = 0.787	p = 0.033
	rural	81	1 (ref)	1 (ref)
	urban	45	0.878 (0.343–2.248)	0.345 (0.129–0.918)
BCG vaccination			p = 0.668	p = 0.751
	no	27	1.306 (0.385–4.431)	0.842 (0.291–2.433)
	yes	39	1 (ref)	1 (ref)
co-morbidities			p = 0.371	p = 0.414
	no or unknown	109	1 (ref)	1 (ref)
	yes	18	0.494 (0.106–2.312)	0.579 (0.156–2.148)
alcohol or drug use			p = 0.949	p = 0.243
	no or unknown	116	1 (ref)	1 (ref)
	yes	11	0.949 (0.192–4.707)	0.287 (0.035–2.334)
homelessness			p = 0.753	p = 0.978
	no or unknown	123	1 (ref)	1 (ref)
	yes	4	1.499 (0.144–14.573)	1.033 (0.104–10.310)
microorganism-related
lineage			p = 0.220	-
	EAI	18	0.107 (0.013–0.860); p = 0.036	-
	EAm	65	1 (ref)	-
	EAs	10	0.000 (0.000-.); p = 0.999	-
	IO	31	0.000 (0.000-.); p = 0.998	1
antibiotic resistance			p = 0.659	p = 0.979
	none or unknown	118	1 (ref)	1 (ref)
	resistant	8	1.455 (0.275–7.696)	1.023 (0.196–5.349)
transmissibility			p = 0.003	p = 0.097
	no	49	4.242 (1.650–10.907)	0.467 (0.190–1.148)
	yes	78	1 (ref)	1 (ref)
disease-related
disease localization			p = 0.573	p = 0.002
	pulmonary TB	82	1 (ref)	1 (ref)
	extra-pulmonary TB	24	0.589 (0.156–2.222); p = 0.435	5.279 (1.983–14.049); p = 0.001
	pulmonary and extra-pulmonary TB	20	1.375 (0.435–4.343); p = 0.587	0.788 (0.205–3.038); p = 0.730