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. 2015 Jun 2;10(6):e0129060. doi: 10.1371/journal.pone.0129060

Fig 2. Periodontal treatment and low birth weight (LBW).

Fig 2

(A) Conventional meta-analyses were conducted to analyze the effect of periodontal treatment for populations with moderate (<20%) and high occurrence (≥20%) of LBW as well as in the total population. (B) Trial sequential analysis of trials in population with moderate occurrence of LBW. The Z-curve only initially crosses the conventional boundary, with trial sequential monitoring boundary (TSMB) for benefit and HRIS not being in reach. (C) Trial sequential analysis of trials in population with high occurrence of LBW. The Z-curve does not reach the HRIS, and does not cross the TSMB.