Fig 2. Mediators of body mass index-related cardiovascular disease risk.

The figure shows hazard ratios per 5 kg/m² higher body mass index adjusted for sex and age and different combinations of mediators for the combined event. Panel A shows the mediating effects of glucose, cholesterol, and blood pressure, and their combination. Panel B shows the mediating effects of adiponectin, leptin, and C-reactive protein (CRP), and their combination. Panel C shows the mediating of adiponectin, leptin, and C-reactive protein, and their combination on the residual body mass index-related risk already adjusted for sex, age, glucose (Glu), cholesterol (Chol), and blood pressure (BP).