Table 3. Associations of Leptin with Incident Cardiovascular Disease in Inter99.

	Model 1 (n = 5,854)		Model 2 (n = 5,800)		Model 3 (n = 5,763)
	Events	HR (95% CI)	Events	HR (95% CI)	Events	HR (95% CI)
Combined events	464	1.17 (1.07–1.28)*	457	1.02 (0.93–1.13)	453	0.97 (0.85–1.12)
IHD	303	1.18 (1.05–1.32)*	299	0.98 (0.87–1.11)	297	0.95 (0.80–1.12)
Stroke	182	1.15 (0.99–1.33)	181	1.10 (0.94–1.29)	179	1.08 (0.87–1.35)

Data are presented as Hazard Ratio per one standard deviation increase in log transformed leptin level. Model 1: Adjusted for sex, age and intervention group. Model 2: Model 1 + total cholesterol, HDL-cholesterol, smoking status, systolic blood pressure, treatment for hypertension and baseline diabetes. Model 3: Model 2 + BMI, HOMA-IR, eGFR, CRP and adiponectin.

*P <0.01