Table 4. Associations of Leptin/Adiponectin Ratio with Incident Cardiovascular Disease in Inter99.

	Model 1 (n = 5,854)		Model 2 (n = 5,800)		Model 3 (n = 5,763)
	Events	HR (95% CI)	Events	HR (95% CI)	Events	HR (95% CI)
Combined events	464	1.20 (1.09–1.32)*	457	1.02 (0.91–1.13)	453	1.00 (0.88–1.15)
IHD	303	1.26 (1.13–1.42)*	299	1.00 (0.89–1.15)	297	1.00 (0.86–1.19)
Stroke	184	1.12 (0.97–1.30)	181	1.07 (0.90–1.26)	179	1.08 (0.88–1.33)

Data are presented as Hazard Ratio per one standard deviation increase in log transformed Leptin/Adiponectin ratio. Model 1: Adjusted for sex, age and intervention group. Model 2: Model 1 + total cholesterol, HDL-cholesterol, smoking status, systolic blood pressure, treatment for hypertension and baseline diabetes. Model 3: Model 2 + BMI, HOMA-IR, eGFR and CRP.

*P <0.001