Table 1.
Iminosugars are potent ER α-glucosidase inhibitors and can inhibit viral replication in vitro. UV-12 was tested for the ability to inhibit rat liver ER α-glucosidases I and II on oligosaccharide substrates, Glc(1-3)Man(4-7)GlcNAc(1-2) isolated from cultured cells. The mean and SD of the IC50 from triplicate assays is shown. Viral inhibition was tested using a yield/plaque assay with multiple concentrations of UV-12. The mean from duplicate assays is shown.
| Compound | α-glc I | α-glc II | Virus | |||
|---|---|---|---|---|---|---|
| Glc3 | Glc2 Glc1 | DENV-2 | INFV | VEEV | ||
| UV-12 | 0.14 ± 0.10 μM | 1.10 ± 0.48 μM | 0.83 ± 0.37 μM | 21.71 μM | >250 μM | 69.4 μM |