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In vitro ADME properties of UV-12.
| Caco-2 permeability | Efflux Ratio | 4 | |
| Plasma protein binding (% bound at 10 uM) | Human | 68% | |
| Dog | 72% | ||
| Rat | 68% | ||
| Mouse | 64% | ||
| Liver microsome metabolic stability (0.5 mg/mL protein concentration) | CLintr (mL/min/g liver) | Half-life (min) | |
| Human | <0.6 | >30 | |
| Dog | <0.6 | >30 | |
| Rat | <0.6 | >30 | |
| Mouse | <0.6 | >30 | |
| CYP inhibition (IC50) | CYP1A2 | >100 μM | |
| CYP2C9 | >100 μM | ||
| CYP2C19 | >100 μM | ||
| CYP2D6 | >100 μM | ||
| CYP3A4a | >100 μM | ||
| hERG Inhibition | >300 μM | ||
| Mini-Ames | Not mutagenic up to 5mg/plate | ||
