Table 3.
Mean pharmacokinetic parameters of UV-12 in male Swiss Albino mice.
| Route/Dose(mg/kg) | Tmax (h) | Cmax (μg/mL) | AUClast a (μg.h/mL) | AUCinf a (μg.h/mL) | CL (mL/min/kg) | Vss (L/kg) | T1/2 (h) | F b |
|---|---|---|---|---|---|---|---|---|
| IV/10 | NA | 8.88c | 5.90 | 5.91 | 28.22 | 1.98 | 1.92 | - |
| PO/100 | 0.5 | 12.59 | 43.14 | 45.54 | NC | NC | NC | 77 |
a AUClast calculated using data through 8 h and AUCinf calculated using data extrapolated to infinity. b AUCinf and nominal doses were used for bioavailability calculations; c back extrapolated concentration at time zero; NA: Not applicable; Regression points (4, 8 and 16 h) were selected for both routes to calculate elimination rate constant. NC: Data results were not suitable to calculate Cl, Vss, and T½ for the oral route.