Table 4.
Mean pharmacokinetic parameters of UV-12 in female Hartley guinea pigs.
| Route | Dose (mg/kg) | Tmax a (h) | Cmax (ng/mL) | AUClast (ng.h/mL) | AUCinf (ng.h/mL) | CL (mL/min/kg) | Vss (L/kg) | T1/2 (h) | F b |
|---|---|---|---|---|---|---|---|---|---|
| SC | 100 | 0.5 | 11,035 ± 3165 | 23,023 ± 5043 | 23,078 ± 5060 | NC | NC | 2.21 ± 0.37 | 131 |
| IM | 100 | 0.25 | 11,636 ± 2247 | 19,122 ± 2088 | 19,168 ± 2094 | NC | NC | 1.99 ± 0.91 | 109 |
| IV | 25 | NA | 8855c ± 470 | 4368 ± 583 | 4398 ± 599 | 95.89 ± 12.69 | 5.14 ± 0.64 | 1.40 ± 0.09 | NA |
a Tmax reported as median (min-max); b AUCinf and nominal doses were used for absolute bioavailability (F) calculation; c back extrapolated concentration at time zero; NA: Not applicable for IV route; NC: Data results were not suitable to calculate CL and Vss for the SC and IM routes.