Figure 1.

Structure of the model. A_c and A_h represent drug amounts in the chemotherapy and hormonotherapy compartments, respectively (arbitrary unit (AU)). K_c and K_h are the chemotherapy and hormonotherapy kinetic rate constants, respectively (day⁻¹). A50_c and A50_h are the amounts of each treatment producing 50% of the maximum effect (AU), respectively. Kin_LV and Kout_LV are the latent variable production and elimination rate constants (AU.day⁻¹ and day⁻¹), respectively. Kin_PSA and Kout_PSA correspond to the prostate-specific antigen (PSA) production and elimination rate constants (ng.mL⁻¹.day⁻¹.AU⁻¹ and day⁻¹), respectively. K0 is the circulating tumor cells (CTC) production rate (CTC.day⁻¹.AU⁻¹). CTC_Total and CTC_Obs are the CTC counts in the total body blood and in the aliquot, respectively. α corresponds to the scaling factor and OVDP to the overdispersion parameter. LV, latent variable.